By Matthew Jonathan Murray, Stefan Schönberger MD (auth.), A. Lindsay Frazier, James F. Amatruda (eds.)
Germ phone tumors are quite infrequent in comparison with different malignancies, and compilations of information that surround the total spectrum of the ailment are missing. This textbook, written by means of the main professionals within the box, rectifies the placement by means of discussing intensive a extensive variety of issues, together with biology, epidemiology, pathology, therapy, and past due results. considering that germ mobilephone tumors are such a lot commonly used within the adolescent and younger grownup age team, motives of ailment and therapy methods in pediatric and grownup sufferers are in comparison and contrasted. through spanning the full lifestyles direction, from prenatal origins of disorder via to therapy in adults and overdue results of remedy, the editors have produced a publication that would be of curiosity to either pediatric and grownup oncologists.
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Additional info for Pediatric Germ Cell Tumors: Biology Treatment Survivorship
J Pediatr Surg 33:1122– 1126; discussion 1126–1127 Biggs ML, Davis MD, Eaton DL, Weiss NS, Barr DB, Doody DR, Fish S, Needham LL, Chen C, Schwartz SM (2008) Serum organochlorine pesticide residues and risk of testicular germ cell carcinoma: a populationbased case–control study. Cancer Epidemiol Biomarkers Prev 17:2012–2018 Biggs ML, Schwartz SM (2004) Differences in testis cancer survival by race and ethnicity: a population-based study, 1973–1999 (United States). Cancer Causes Control 15:437–444 Boisen KA, Main KM, Rajpert-De Meyts E, Skakkebaek NE (2001) Are male reproductive disorders a common entity?
Cancer Causes Control 15:437–444 Boisen KA, Main KM, Rajpert-De Meyts E, Skakkebaek NE (2001) Are male reproductive disorders a common entity? The testicular dysgenesis syndrome. Ann N Y Acad Sci 948:90–99 Bouskine A, Nebout M, Brucker-Davis F, Benahmed M, Fenichel P (2009) Low doses of bisphenol A promote human seminoma cell proliferation by activating PKA and PKG via a membrane G-protein-coupled estrogen receptor. Environ Health Perspect 117:1053–1058 Bouskine A, Nebout M, Mograbi B, Brucker-Davis F, Roger C, Fenichel P (2008) Estrogens promote human testicular germ cell cancer through a membranemediated activation of extracellular regulated kinase and protein kinase A.
Family history has been evaluated in the literature, with mixed results. A study of 74 cases of ovarian GCT found none with a family history (Shulman et al. 1994), while other reports have described families with cases of both ovarian GCT and either TGCT or extragonadal GCT (Giambartolomei et al. 2009). The few risk factors that have been evaluated include inflammatory cytokines during pregnancy (Toriola et al. 2011) and maternal hormone exposure in cases diagnosed before age 35 years (Walker et al.