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By R. S. Reneman, P. A. J. Janssen (auth.), Prof. Dr. med. A. Doenicke (eds.)

The query how one can set off common anaesthesia effortlessly has been requested many times by means of anaesthetists and pharmacologists. P. A. JANSSEN built etomidate and released this substance in 1971 as "a powerful short-acting and comparatively atoxic intravenous hypnotic agent in rats". In 1974 after numerous years of experimental and medical trial the barbiturate-free hypnotic etomidate (soon advertised as Hypnomidate) used to be brought to various auditors on the party of the IV. eu Congress of Anaesthesiologists in Madrid. because the authors prolonged their essays, the reality of the current booklet is given. the belief mentions the hot answer of etomidate base in 35 % propylene glycol. it really is anticipated that the disadvantageous results - venous soreness in the course of injection and linked involuntary muscle flow- will principally be eradicated by utilizing the hot formulation of etomidate after premedication of fentanyl. Mlinchen, August 1977 Alfred DOENICKE desk OF CONTENTS The Experimental Pharmacology of Etomidate, a brand new powerful, Short-Acting Intravenous Hypnotic (R. S. RENEMAN and P. A. JANSSEN) •. . . . •• 1 Protein Binding of Etomidate (G. A. MANNES and A. DOENICKE) ••••. . . 6 The impact of Intra-Arterial Injection of Etomidate and Thiopental at the Skeletal Muscle- and Arterial Wall-Structures (R. S. RENEMAN, F. VERHEYEN, R. KRUGER, W. VAN GERVEN and M. BORGES) . . •. . •• nine interplay among Etomidate and the Antihypertensive brokers Propanolol andoC-Methyl-Dopa (R. S. RENEMAN, W. VAN GERVEN and R. KRUGER) ••. •. . . 15 Teratogenicity of Etomidate (A. DOENICKE and M. HAEHL) •. ••. •.

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Etomidate: An Intravenous Hypnotic Agent First Report on Clinical and Experimental Experience

The query the way to result in common anaesthesia easily has been requested many times via anaesthetists and pharmacologists. P. A. JANSSEN built etomidate and released this substance in 1971 as "a effective short-acting and comparatively atoxic intravenous hypnotic agent in rats". In 1974 after numerous years of experimental and scientific trial the barbiturate-free hypnotic etomidate (soon advertised as Hypnomidate) used to be brought to varied auditors on the celebration of the IV.

Additional info for Etomidate: An Intravenous Hypnotic Agent First Report on Clinical and Experimental Experience

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Acknowledgement The authors are indebted to Mr. J. Dony for his help in the statistical evaluation of the results and to Mr. J. Lambregts for his technical assistance. 22 Summary In this study the interaction between the anti-hypertensive agents propranolol andOC-methyl-dopa and etomidate was studied in unpremedicated, non-anaesthetized labradors. No interference was found between these anti-hypertensive drugs and etomidate, at least as far as the effect on heart rate, systolic and diastolic aortic blood pressure, respiratory rate and duration of sleep is concerned.

03 mg/kg . h). The acid-base balance was intermittently determined by blood gas analyses, and corrected upon the limits of deviations from the norm. The exposed arteries and veins were cannulated after the administration of 5 mg/kg heparine under radiological control. Every two hours, 2 mg/kg of heparine was administered as a follow-up injection. pu m ventricular end-diastolic pressure (P LVED )' A catheter tip-manometer (Millar PC 350) facilitated pressure-reading in the left ventricle. The rate of rise in left ventricular pressure (dp/dt) was determined by differentiation (RC coupled) of the pressure curve.

Etomidate and piritramide did not affect these haemodynamic parameters. 5. Coronary blood flow (Vcor ) and coronary vascular resistance (W cor ) (Fig. 4) In comparison with the remaining anaesthetics the increase in coronary blood flow after propanidid (114 %) was enormous, although limited to a short period (about 3 minutes); a remarkable increase, however, was also recorded after Althesin (47 %), 54 Table 1. 96 + 81. 7 9. 6 55 pressure (CVP), coronary blood flow (Vcor )' coronary vascular resistance (Wcor )' arterio-coronary venous difference in oxygen (AVD0 2 cor)' myocardial oxygen consumption (MV0 2 ), and of the efficiency of cardiac work (~) in each animal group.

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