By Mario E. Lacouture
This is often the 1st e-book to target common and regularly disabling negative effects concerning the surface, hair, and nails in melanoma sufferers. It presents unique descriptions of mechanism-of-action in all present oncology medications and the scientific presentation and mechanisms underlying their dermatologic negative effects, along rigorously awarded therapy thoughts, permitting physicians to noticeably increase their care of sufferers with melanoma. while present oncology and dermatology textbooks simply in short take care of this subject, this source deals dermatologists and different practitioners a concentrated viewpoint on cancer-related dermis stipulations.
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Additional resources for Dermatologic Principles and Practice in Oncology: Conditions of the Skin, Hair, and Nails in Cancer Patients
Journal of the American Medical Association, 132, 126–132. 9 Gilman, A. S. (1946) The biological actions and therapeutic applications of the B-chloroethyl amines and sulfides. Science, 103, 409–436. I. (1965) The effectiveness of combinations of antileukemic agents in inducing and maintaining remission in children with acute leukemia. Blood, 26, 642–656. , Danneberg, P. et al. (1957) Fluorinated pyrimidines: a new class of tumour-inhibitory compounds. Nature, 179, 663–666. A. N. (1989) Muromonab CD3: a review of its pharmacology and therapeutic potential.
Since the initial description of chemotherapy-induced alopecia (CIA) in the 1950s [36,37], this particular adverse event has remained one of the most significant and prevalent toxicities . Fifty-eight percent of women undergoing alopecia-inducing therapy consider it the most distressing AE and 8% would potentially avoid chemo therapy in anticipation of this toxicity . Multiple agents are known to cause alopecia, including paclitaxel (>80%), doxoru bicin (60–100%), cyclophosphamide (>60%), and 5-fluorouracil (10–50%) .
Hair matrix cells phagocytose eumelanin or pheomelanin from dendritic elongations of melanocytes. This is how hair assumes its color: black if eumelanin is dominant, and yellow or red if pheomelanin is the major pigment. Nails In addition to serving an aesthetic purpose, nails enhance tactile senses and the biomechanics of fingers and toes. Nails can be affected in a number of disease states or responses to therapy, and a basic appreciation for the structure and function of nails may aid the clinician in detecting abnormal physiologic states.