By A. R. Prévot (auth.), Bernard Halpern (eds.)
In his advent to the Ciba origin Symposium on "Immunopotentia tion," Sir Peter Medawar said that, "for the earlier 20 years the keep an eye on of the immune reaction has been nearly equated to immunosuppression as the nice objective of utilized immunology has been the transplantation of tissues," and that, "with the invention of tumor immunity-the point of interest of immuno logical keep an eye on has replaced from immunosuppression to immunpotentiation and correspondingly the nice prize of utilized immunology has develop into the preven tion and keep watch over of malignant growth." Corynebacterium parvum is now univer sally well-known as being the main powerful almost immediately identified immunopotentiator. C parvum is on the heart of virtually all papers provided at this convention and it's been analyzed from quite a few viewpoints: taxonomy, pharmacology, immunopotentiation, stimulation of host resistance to tumor invasion in experi psychological versions and in human therapeutics. just about all information suggested during this quantity are unique and lately acquired. The discussions have been spontaneous, stimulating, and hugely enriching, and the implications already proven and re ported listed below are in lots of respects exact. Discussions on the convention published many different features which require additional exploration. Nonspecific immunopotentiation has strongly penetrated into immunology, immunopathology, and, lately, oncology. certainly, this sector of analysis will witness vital advancements within the close to destiny. This booklet bargains the 1st synthesis of shortly on hand wisdom and emphasizes destiny prospects.
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Additional info for Corynebacterium Parvum: Applications in Experimental and Clinical Oncology
Lewis tumor and ICIG CI I are susceptible to enhancement. The tests of activity in the three tumor systems were preceded by screening for immunological activity in two nontumorous systems. After preliminary experiments (Mathe et al.. 1971), the following were chosen: (a) the hemolytic plaque-forming cell test (Jerne et al.. , 1966). Finally, this last test enabled us to detect a possible immuno-inhibition as well as an immunostimulation in response to cell-surface antigens. In summary, this battery can answer these important questions: Is a given agent an immuno-adjuvant or an immuno-inhibitor, or both, depending on time and route factors?
Lymphoreticular stimulatory properties of Corynebacterium parvum and related bacteria. J. Med. Microbiol. 6:261. Active Principle of C. parvum 39 Novotny, P. (1964). A simple rotary disintegrator for microorganisms and animal tissues. ) 202:364. Prevot, A. R. and Thouvenot, H. (1964). Inhibition de la synthese de la reticulostimuline chez les souches Iysoglmes de Corynebacteries anaerobies. R. Acad. Sci. 259: 1447. Prevot, A. , and Thouvenot, H. (1968). Influence des parois cellulaires du Corynebacterium parvum (souche 936 B) sur Ie systeme reticulo-endothelial de la souris.
And Sharp, J. J. (1960). Studies of arthritis and other lesions induced in rats by injection of mycobacterial adjuvant II. Evidence that the disease is a disseminated immunologic response to exogenous antigen. J. Immunol. 85:403-447. Werner, G. , and Jones, P. (1974). Activites biologiques des adjuvants hydrosolubles de faible poids moleculaire extraits de Mycobacterium tuberculosis var. hominis. C. R. A cad. Sci. 278 D:789-792. White, R. , Johns, R. , and Lederer, E. (1958). The influence of components of M tuberculosis and other mycobacteria upon antibody production to ovalbumin.