Download Contemporary Topics in Immunobiology: Volume 1 by A. J. S. Davies, R. L. Carter (auth.), M. G. Hanna Jr. PDF

By A. J. S. Davies, R. L. Carter (auth.), M. G. Hanna Jr. (eds.)

Investigators, lecturers, and practitioners within the biomedical sciences are keenly conscious of the present predicament in medical communications. With good over one thousand biomedical journals generating new concerns every month, and with nearly new technical books in biomedicine being 1 released every year, let alone the proliferation of information-ex­ swap conferences, it's all too transparent that we're at risk of being inundated by way of a flood of tables, figures, and hypotheses. the matter is especially acute in immunology, because the expense of data creation is expanding geometrically, and immunological methods were prolonged into different organic and scientific fields to extra diversify the examine over an enormous literature. Abstracting and information-retrieval providers do a lot to enhance the investigator's lot, yet don't supply options for one fairly distressing element of the problem. in the course of our informational overabundance, one frequently unearths that interrelationships among an investigator's collective findings have gotten blurred, or that the relation of his overall paintings to the sector are usually not transparent. even supposing assessment articles are integral in solving the prestige of a given challenge, they don't give you the targeted realization to a unmarried author's paintings that's needed.

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As a result of these general findings, it has been proposed that chronic lymphocytic leukemia is a disease primarily affecting the thymus-independent B lymphocytes (Miller, 1967, 1968). Direct proof of the origin of these presumptive B cells is lacking, but some suggestive evidence has come from studies on the cells themselves. Many investigators have shown that most of the circulating lymphocytes in chronic lymphocytic leukemia do not transform in the presence of PHA; this failure is due to an intrinsic defect in the cell and not to some factor in the plasma.

In Good, R. , and Gabrielson, A. , The Thymus in Immunobiology, Harper and Row, New York, p. 395. , 1969. Cell separation on antigen-coated columns. Eliminations of high rate antibody-forming cells and immunological memory cells. J. Exptl. Med. 129:23. Wostm ann , B. , Pleasants, J. , and Kincade, P. , 1970. Serum proteins and lymphoid tissues in germ-free mice fed a chemically defmed, water soluble, low molecular weight diet. Immunology 19:443. , 1970. Human thymus-lymphoid tissue antigen and its presence in leukemia and lymphoma.

1961. Homologous and heterologous skin transplantation in patients with lymphomatous disease. J. Nat!. Cancer Inst. 26:569. Miller, J. F. A. , 1965. Effect of thymectomy in adult mice on immunological responsiveness. Nature (London), 208: 1337. Miller, J. F. A. , and Brunner, K. , 1970. Thymus-derived cells as killer cells in cell-mediated immunity. Third Internat. Congr. , The Hague, September 1970. Miller, J. F. A. , and Davies, A. J. , 1964. Embryological development of the immune mechanism.

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