By Robert D. Goldman, Robert V. Zackroff, Peter M. Steinert (auth.), Robert D. Goldman, Peter M. Steinert (eds.)
Research job on intermediate filaments (IF) has elevated dramatically during the last decade. For the main half, this surge of curiosity is because of their identity as ubiquitous components of the cytoskeleton and karyoskeleton (nuclear matrix) of eukaryotic cells and the truth that we all know little or no relating to their services. In sharp distinction to the opposite significant cytoskeletal platforms, microfilaments and microtubules, IF show a excessive measure of heterogeneity with reference to their protein subunit composition. certainly, you'll purely surprise on the variety of diversified IF polypeptides, their linked proteins (IFAP) and, accordingly, the variety of genes taken with encoding the a number of parts of a number of the IF networks present in diverse mobilephone forms. The chapters during this e-book reveal how numerous experimental methods involv ing mobile, molecular, biochemical, and immunological tools were applied to generate information about the constitution and serve as of IF. To this finish, now we have amassed jointly chapters from specialists within the significant fields of IF study. In each one bankruptcy, the authors have mixed reports of the to be had medical literature with their very own rules on present and destiny instructions for IF examine. The chapters were divided into 5 significant sections that are curious about the subcellular association of IF, the molecular constitution of IF, the differential expression of IF genes, descriptions of associ ated proteins enthusiastic about the intracellular association of IF, and at last an research of the adjustments visible in IF in pathological conditions.
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Additional info for Cellular and Molecular Biology of Intermediate Filaments
And Goldman, R. , 1979. In vitro assembly of intermediate filaments from baby hamster kidney (BHK-21) cells, Proc. Natl. Acad. Sci. USA 76:6226-6230. 2 Intermediate (IO-nm) Filaments in Muscle Marvin H. Stromer 1. Introduction The purpose of this chapter is to provide an overview of 1O-nm filaments in smooth, skeletal, and cardiac muscle with an emphasis on newer developments. The intent was not to provide an exhaustive literature review but, instead, to include a sampling of research from different laboratories.
Stromer • Muscle Biology Group, Department of Animal Science, Iowa State University, Ames, Iowa SOOll. 19 20 Marvin H. Stromer Peripheral to this bundle, smooth muscle cell cytoplasm contains many 10-nm filaments that are oriented predominantly parallel to the long axis of the spindle-shaped cell. , 1975) or saponin-skinned vascular muscle (Garfield and Somlyo, 1985) where some lO-nm filaments appear to loop tangentially near cytoplasmic dense bodies or are obliquely arranged between dense bodies.
Kaufmann et al. (198S) found that thrombin removed 67 residues from the amino-terminal end of desmin and that the remaining fragments were not capable of forming filaments. 2. Removal of the carboxyl-terminal 27 residues with a lysine-specific protease produced a fragment that formed normal filaments when the salt concentration was reduced to SO mM. Removal of a 4-kDa peptide from the amino-terminus of vimentin also prevented the remainder of the molecule from assembling into filaments (Traub and Vorgias, 1983).