Download Biology and Management of Lung Cancer by Desmond N. Carney, Adi F. Gazdar, Herbert K. Oie (auth.), F. PDF

By Desmond N. Carney, Adi F. Gazdar, Herbert K. Oie (auth.), F. Anthony Greco (eds.)

Lung melanoma continues to be a really tricky neoplasm to regard successfully. a wide a part of our loss of good fortune in facing those sufferers is said to our empiric healing makes an attempt. Slowly our simple realizing of the lung cancers is enhancing and methods have gotten to be had to permit us to raised comprehend the biology of those neoplasms. This quantity reports numerous parts of curiosity in regard to the biologic habit and characteris­ of lung melanoma. tics Chapters take care of the in vitro development of small mobile lung melanoma, the inves­ tigation of development components in human lung melanoma, the construction of mono­ clonal antibodies opposed to lung melanoma and the applying and capability use­ fulness of the human tumor cloning assay in lung melanoma administration. those avenues of research tend to determine a extra clinical foundation on which extra rational treatment could be designed. Carney and colleagues have proven a number of non-stop small cellphone lung melanoma mobile traces of their laboratory. The amine precursor uptake and decar­ boxylation (APUD) houses of this neoplasm were proven by way of demonstrating the presence of neurosecretory granules and excessive degrees of the APUD enzyme L-dopa decarboxylase. additionally, a number of new markers were documented together with bombesin, creatine-kinase BB and neuron­ particular enolase. those tumor items besides others could be worthwhile serum markers in sufferers with small cellphone lung cancer.

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Carney DN, Gazdar AF, Bunn PA Jr, Minna JD: In vitro cloning of small cell carcinoma of the lung. In: Small Cell Lung Cancer Greco FA (eds). New York: GTUne & Stratton, 1981, pp 74-94. Buick RN, Fry SE, Salmon SE: Effect of host cell interactions on clonogenic carcinoma cells in human malignant effusions. Brit J Cancer 41: 695-704, 1980. : Utilization of a human tumor cloning system to monitor for marrow involvement with small cell carcinoma of the lung. Cancer Res 41:1015-1020,1981. Callaghan SK, Von Hoff DD: Growth of oat cell carcinoma of the lung in human tumor cloning assay.

9. Levy R, Dilley J, Fox RI, Warnke R: A human thymus-leukemia antigen defined by hybridoma monoclonal antibodies. Proc Natl Acad Sci USA 76:6552-6556, 1979. 10. Rite J, Pesando JM, Notis-McConarty J, Lazarus H, Schlossman SF: A monoclonal antibody to human acute lymphoblastic leukaemia antigen. Nature 283: 583-585, 1980. II. Koprowski H, Steplewski Z, Herlyn D, Herlyn M: Study of antibodies against human melanoma produced by somatic cell hybrids. Proc Natl Acad Sci USA 75:3405-3409, 1978. 12. Imai K, Ng A, Ferrone S: Characterization of monoclonal antibodies to human melanomaassociated antigens.

Acad Sci USA 77:6114-6118,1980. 35 15. Cuttitta F, Rosen S, Gazdar AF, Minna JD: Monoclonal antibodies which demonstrate specificity for several types of human lung cancer. Proc Natl Acad Sci USA 78:4591-4595, 1981. 16. : Methods for production of monoclonal antibodies with specificity for human lung cancer cells. In vitro 17: 1058-1070, 1981. 17. Mazauric T, Mitchell KF, Letchworth GJ, Koprowski H, Steplewski Z: Monoclonal antibody-defined human lung cell surface protein antigens. Cancer Res 42: 150-154, 1982.

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