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4. An abundant number of tumor cells proliferating in a lymph node that is almost wholly occupied by tumor cells. 44 Fig. 5. High magnification of a lymph node in which virusinfected xenogenized tumor cells grow well. Ai**:'"- . ·■:*, \ Λ Fig. 6. The lymph node, however, begins to shrink, and tumor cells disappear gradually. 45 Fig. 7. Finally, the normal structure of the lymph node ap­ pears again. No perceptible signs exist that there was tumor metastasis in the lymph node. Fig. 8. A new antigen appearing on the cell surface as indi­ cated by granules of immunoferritin.

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Hauschka, T. S. (1953). J. Nati. Cancer Inst. (US) 14, 723-736. Heppner, G. H. (1982). In "Tumor Cell Heterogeneity Origins and Implications" (A. H. , D. S. Coffey, and S. B. ), pp. 225-236. Academic Press, New York. Heppner, G. , and Miller, B. E. (1983). Cancer Metastasis Rev. 2, 5-23. Heppner, G. , Dexter, D. , Miller, F. , and Calabresi, P. (1978). Cancer Res. 38, 3758-3763. , Cooper, D. , and Miller, F. R. (1980). In "Cell Biology of Breast Cancer" (C. M. McGrath, M. J. Brennan, and M. A. ), pp.

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