Download Basic and Clinical Science of Opioid Addiction by Marcus F. Kuntze, Franz Muller-Spahn, Dieter Ladewig, Alex PDF

By Marcus F. Kuntze, Franz Muller-Spahn, Dieter Ladewig, Alex H. Bullinger

For the 1st time, experiences on methadone and heroin upkeep therapy with recognize to scientific perform, learn, methodological features, neuroscience and psychotherapy are introduced jointly during this quantity. They come up from a convention held in November 2001 in Basel. The Swiss technique of a hugely established outpatient therapy utilizing methadone, heroin, morphine and so on. to maintain sufferers in therapy is mentioned. facts of follow-up after heroin-assisted remedy is proven. additionally a severe dialogue of the background of therapy modalities and its clinical overview is gifted. extra vital subject matters corresponding to mind imaging, opioid withdrawal, hazards of therapy, and simple neurochemical examine are offered. the problem concludes with the narrative event of a practising psychotherapist. This topical and notable assessment comes in handy for psychiatrists, psychologists and psychotherapists, neuroscientists, physicians in addition to selection makers in public health and wellbeing, politicians, counselors and social employees an exceptional perception into stimulating and medical study.

Show description

Read Online or Download Basic and Clinical Science of Opioid Addiction PDF

Similar clinical books

Dyslipidaemia in Clinical Practice, 2nd Edition

The second one variation bargains the reader the very most modern info on lipid issues from aetiology to the administration of this ever expanding challenge that may be a significant reason for atherosclerotic and heart problems. Written via a medical professional, an epidemiologist, and a lipidologist, this concise and well-illustrated textual content will entice quite a lot of experts who're dealing more and more with dyslipidaemia.

Adenosine, Cardioprotection and Its Clinical Application

The colossal development within the variety of articles on adenosine cardioprotection lately has been similar largely to the speculation that adenosine performs a job in ischemic preconditioning. Ischemic preconditioning is the phenomenon during which a quick interval of ischemia (and reperfusion) ahead of a extra lengthy occlusion reduces myocardial infarct dimension.

Etomidate: An Intravenous Hypnotic Agent First Report on Clinical and Experimental Experience

The query how one can result in normal anaesthesia easily has been requested many times via anaesthetists and pharmacologists. P. A. JANSSEN constructed etomidate and released this substance in 1971 as "a powerful short-acting and comparatively atoxic intravenous hypnotic agent in rats". In 1974 after a number of years of experimental and medical trial the barbiturate-free hypnotic etomidate (soon advertised as Hypnomidate) used to be brought to various auditors on the get together of the IV.

Extra info for Basic and Clinical Science of Opioid Addiction

Sample text

Dr. O. com Rehm 38 Neurosciences Kuntze MF, Müller-Spahn F, Ladewig D, Bullinger AH (eds): Basic and Clinical Science of Opioid Addiction. Bibl Psychiatr. Basel, Karger, 2003, No 170, pp 39–45 Dopaminergic Dysfunction – A Common Final Pathway of Addiction to Alcohol, Opiates and Nicotine? Lutz G. Schmidt a, Michael N. Smolkab, Hans Rommelspacher b a b Department of Psychiatry, University of Mainz; Department of Addictive Behavior and Addiction Medicine, Central Institute of Mental Health, University of Heidelberg, Mannheim, Germany Numerous studies have shown that natural rewards, including food, drinks and sex and many drugs of abuse interact with the central brain system by enhancing dopamine turnover in certain sites following acute administration, especially the mesolimbic-mesocortical circuitry [1].

In the case of psychostimulants and opioids, in vivo measurements of extracellular dopamine levels have provided direct evidence that these drugs, when administered under an intermittent injection schedule, can lead to a more pronounced increase in dopamine levels than the increase seen after acute administration of these drugs [1]. However, rats that received repeated intermittent injections of alcohol did not show sensitization of alcohol-induced dopamine release in the nucleus accumbens. Current conceptualizations of the significance of sensitization in compulsive drug-seeking behavior hold that rather than enhancing the reward, repeated drug use leads to a progressive and persistent hypersensitivity of neural systems that mediate incentive salience, possibly resulting in drug or alcohol craving and relapse [4–6].

Conclusions with Respect to Randomized Controlled Clinical Trials in Opioid-Assisted Substitution Therapy Randomized controlled clinical trials did not seem to be feasible in research on opioid-assisted substitution therapy. Specifically blinding of patients and caregivers seems to be impossible. It is thus suggested that such trials be conducted unblinded but incorporate expectations of patients and caregivers and explicitly measure content and level of the care given. With respect to other standards of control, randomization may be possible but effects of expectations should be carefully considered in design and interpretation.

Download PDF sample

Rated 4.45 of 5 – based on 33 votes

About admin