Download Bacterial Adhesion: Chemistry, Biology and Physics by Jack C. Leo, Mikael Skurnik (auth.), Dirk Linke, Adrian PDF

By Jack C. Leo, Mikael Skurnik (auth.), Dirk Linke, Adrian Goldman (eds.)

Adhesion performs a tremendous position within the bacterial way of life. micro organism can adhere to natural and inorganic surfaces, to one another, and naturally to host cells in the course of pathogenesis.

The concentration of this ebook is: how are such adhesion phenomena top studied? Microbial genetics experiments have enormously more advantageous our wisdom of what bacterial elements are fascinated by adhesion. for varied purposes, although, biochemical and structural biology wisdom of the molecular interactions fascinated by adhesion are restricted. One serious problem has been an absence of interdisciplinary examine and knowing within the box. at the one hand, the microbiologists lack special wisdom of the biophysical chances and feature constrained entry to the often dear instrumentation concerned whereas nonetheless, the specialists in those tools often do not need entry to the organic fabrics, nor do they inevitably comprehend the organic inquiries to be replied. the aim of this ebook is hence to beat this hole in conversation among researchers in biology, chemistry and physics and to reveal the various methods and capacity to enquire bacterial adhesion. we are hoping to stimulate new and ground-breaking research.

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Additional resources for Bacterial Adhesion: Chemistry, Biology and Physics

Sample text

Infections lead to diseases that can cause severe health problems, mainly in developing countries or in patients with compromised immune status, such as children, elderly people or HIV patients. In addition, the presence of Salmonella in livestock animals is known to have a serious impact on economy. Diseases caused by Salmonella lead to different outcomes, depending on the serotype encountered and the immune status of the host. While the serovars Typhimurium or Enteritidis cause self-limiting gastroenteritis in humans, infections with serovars Typhi or Paratyphi lead to typhoid fever, a severe systemic disease.

Such approaches could be complemented by structural analyses of Salmonella adhesins leading to functional understanding of the adhesive properties on the atomic level. Despite our detailed knowledge of several Salmonella adhesins, we expect a large number of unexpected new findings to be made for the adhesion mechanisms of this versatile and successful pathogen. 30 C. Wagner and M. Hensel Acknowledgements Work in our laboratory was supported by grants of the Deutsche Forschungsgemeinschaft (DFG) and the Staedtler-Stiftung.

J Bacteriol 178(3):662–667 Collinson SK, Doig PC, Doran JL, Clouthier S, Trust TJ, Kay WW (1993) Thin, aggregative fimbriae mediate binding of Salmonella enteritidis to fibronectin. J Bacteriol 175:12–18 Collinson SK, Emody L, Muller KH, Trust TJ, Kay WW (1991) Purification and characterization of thin, aggregative fimbriae from Salmonella enteritidis. J Bacteriol 173:4773–4781 Craig L, Li J (2008) Type IV pili: paradoxes in form and function. Curr Opin Struct Biol 18: 267–277 Crawford RW, Reeve KE, Gunn JS (2010) Flagellated but not hyperfimbriated Salmonella enterica serovar Typhimurium attach to and form biofilms on cholesterol-coated surfaces.

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