By François-Xavier Theillet, Pierre Chassagne (auth.), Paul Kosma, Sven Müller-Loennies (eds.)
Many pathogens and aberrant malignant cells convey particular carbohydrates on their floor representing beautiful objectives for vaccine layout. enormous development has lately been made within the id of novel carbohydrate established vaccines and a mess has reached scientific part experiences. The luck of numerous authorized carbohydrate dependent vaccines opposed to bacterial pathogens resembling Haemophilus influenzae kind b, Neisseria meningitidis or Streptococcus pneumoniae demonstrates their nice capability. even though, the research of anti-carbohydrate antibodies is technically demanding and partially due to low affinities and promiscuous specificity they've got now not been medically exploited to complete capability. The research of antibody specificities and identity of protecting carbohydrate epitopes lies on the middle of winning vaccine layout. as well as remedy, antibodies ordinarily function diagnostic instruments in clinical and medical laboratories. during this environment excessive affinity and beautiful specificity are vital components for his or her winning use. “Anticarbohydrate Antibodies – from molecular foundation to medical software” compiles present wisdom at the immunological acceptance of carbohydrates via the adaptive immune method from a molecular viewpoint delivering primary perception wanted for advancing clinically suitable diagnostics and healing functions. in accordance with major growth within the fields of glycoimmunology and structural biology in recent times, the publication comprehensively studies the cutting-edge in defining the major components of carbohydrate popularity by way of antibodies, the molecular mimicry of carbohydrate epitopes in addition to the molecular beneficial properties resulting in particular and comfy binding modes. Backed-up by means of a mixture of contemporary applied sciences to clarify structural info of carbohydrate-antibody interactions, biomedically vital carbohydrate antigens from viral, bacterial, parasite, insect and tumor cells were analyzed in in-depth stories written by means of famous specialists within the box. primary wisdom of those molecular mechanisms finally offers a rational foundation to enhance efficacy of carbohydrate-based vaccines and to extra refine diagnostic instruments in detection of pathogens and malignant cells.
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Extra resources for Anticarbohydrate Antibodies: From Molecular Basis to Clinical Application
2005). Left: Chimeric glycopeptide comprising the rhamnose trisaccharide A2B2C2 a-linked to a MDW tripeptide aglycone (Hossany et al. 2009) data, a chimeric glycopeptide whereby the NMHAA portion was replaced by the a-linked A2B2C2, was designed to ensure appropriate fit of rhamnose C2 in the deep pocket within the SYA/J6 combining site and prevent major entropic loss upon binding. However, competitive inhibition ELISA studies demonstrated that the chimeric glycopeptide did not inhibit SYA/J6 binding to SFY LPS (Hossany et al.
Biochemistry 41: 13575–13586 Vyas NK, Vyas MN, Chervenak MC, Bundle DR, Pinto BM, Quiocho FA (2003) Structural basis of peptide-carbohydrate mimicry in an antibody-combining site.
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