By Priv.-Doz. Dr. med. Rainer Haas, Dr. med. Ralf Kronenwett, Priv.-Doz. Dr. rer. nat. Georg Sczakiel (auth.)
This ebook offers an outline of the present state-of-the-art in peripheral blood stem cellphone transplantation and up to date advancements in molecular analysis and gene healing techniques. the focal point is at the function of peripheral blood stem mobilephone transplantation within the remedy of hematological malignancies akin to non-Hodgkin lymphomas, power myelogenous leukemia and a number of myeloma. present molecular organic thoughts for detecting genetic defects in tumors and minimum residual disorder also are provided. extra themes comprise new gene healing recommendations in hematology and oncology: using viral vectors for transduction of hematopoietic cells is mentioned in addition to healing innovations according to antisense nucleic acids, ribozymes, and immunological approaches.
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Extra resources for Advances in Hematopoietic Stem Cell Transplantation and Molecular Therapy
2 U . 11 Overall survival ::u II!! 4 .!!! 0 0 5 10 15 20 25 30 35 40 4S 50 Survival Time in Months Fig. 2. Overall and event·free survival after PBPCT in 104 patients with multiple myeloma ysis of the French multicenter trial IFM 90 showed a significantly longer event-free and overall survival following high-dose treatment (Attal et al. 1996). Similar results were presented in 1995 by Barlogie et al. at the ASH meeting. The data from the Royal Marsden group (Cunningham et al. 1994) show that high-dose melphalan is the most active agent in the treatment of multiple myeloma.
Strategy for molecular response mOnltonng using quantitative Southern blot (Q-5B) and quantitative polymerase chain reaction (Q-PCR) Follow-up on IFN-a therapy Complete cytogenetic responders after IFN-a Q-SB Q-PCR +++ + ++ +++ +++ ++ ++ Follow-up after allogenous BMT Monitoring after donor lymphocyte transfusion Monitoring after intensive chemotherapy, autologous BMT or stem cell transplantation + + +++ Method of choice; ++ appropriate method; + appropriate method for a certain period of time; - inappropriate method ceived autologous stem cells or bone marrow can be monitored by quantitative PCR and/or quantitative PCR (Table 1).
Immunofluorescence Staining and Flow Cytometry For immunofluorescence analysis, 20 III whole blood or 1xlO6 mononuclear cells were incubated for 30 min at 4°C with the fluorescein isothiocyanate (FITC)-conjugated monoclonal antibody (moAb HPCA-2 (anti-CD34; Becton Dickinson, Heidelberg, Germany) and analyzed using a Becton Dickinson FACScan as previously described (Hohaus et al. 1993). m 2 melphalan alone, because of previous spinal radiotherapy, reduced pulmonary diffusion capacity, or refusal to undergo TBI.