By J. W. Hopewell, W. Calvo, R. Jaenke, H. S. Reinhold, M. E. C. Robbins, E. M. Whitehouse (auth.), PD Dr. Wolfgang Hinkelbein, Dr. Gregor Bruggmoser, Prof. Dr. Hermann Frommhold, Prof. Dr. Michael Wannenmacher (eds.)
Biologists and radiotherapists current their experimental paintings and scientific information within the box of radiation accidents of standard tissues and organs. specific regard is payed to the relevance of organic mechanisms in medical occasions. ideas of radiation harm and mixed therapy toxicity in radio-chemotherapy are being defined. the most themes mentioned are the significance of microvasculature, time, doseand fractionation and elements editing medical radioresponse for early andlate radiation results. Tissues and organs thought of during this quantity are mucosa and pores and skin, lung and center, bladder and muscle, CNS and eye. exact difficulties of pediatric radiotherapy, TBI, IORT and moment malignacies also are mentioned.
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Additional info for Acute and Long-Term Side-Effects of Radiotherapy: Biological Basis and Clinical Relevance
Int J Radiat Bioi 20:184 Blocher D (1988) DNA double-strand break repair determines the RBE of a particles. Int J Radiat Bioi 54:761-771 Curtis HJ (1967) Biological mechanisms of delayed radiation damage in mammals. In: Ebert M, Howard A (eds) Current topics in radiation research, vol 3. NorthHolland, Amsterdam, pp 139-174 Ellis F (1967) Fractionation in radiotherapy. In: Deeley TJ, Wood CAP (eds) Modem trends in radiotherapy, vol 1. Butterworths, London, pp 34-51 Feng Y, Guttenberger R, Thames HD, Stephens LC, Ang KK (1991) Repair kinetics in rat cervical spinal cord: significance for multiple fractions per day treatment.
These are doses at which for a given fractionation schedule and a given treatment volume late normal tissue damage is expected in a certain percentage, say 5% (IDs) , of patients (Rubin and Casarett 1968). As a general rule the accepted incidence of damage decreases with the severity of the side effect, and in a variety of clinical situations only doses well below IDl will be accepted. -H. Hiibener et al. after irradiation, small subsets of patients with increased radiosensitivity caused by such factors may easily affect clinically accepted tolerance doses.
0 Gy per week) or "split-course" radiotherapy, that is an interruption of the treatment for 3 weeks after the first 20 fractions had been applied. Table 3 shows that the dose necessary to obtain 65% local tumor control increased Table 2. Effect of smoking during radiation therapy (RT) on acute mucositis (Rugg et al. 1990) Patient group Number of patients Weeks after start of R T to resolution of mucositis Never smoked Stopped smoking prior to RT Temporary abstinence Continued to smoke during RT 8 18 7 8 12a a Mean values 14 18 23 The Response of Tumors and Normal Tissue to Radiation Therapy 45 Table 3.